I have installed WP Business Directory and it messes up my site. I have tried it with a couple of themes and I get problems with both (Education and Lifestyle themes). I have contacted the plugin's developer and he does seem to be keen to look into this. I have advised him that there are always people on here asking about directory plugins so it would be worth his while making his plugin work properly with Genesis.
I will keep you posted how I get on.
My websites : www.AllergyZone.co.uk